Jin Bu Huan
Common name
N/A
ID
HD0039
Scientific name of the plant
Lypocodium serratum
Anatomical part for use
root
Human use
Pain and inflammation
Summary
Huperzia serrata, the toothed clubmoss, is a plant known as a firmoss which contains the acetylcholinesterase inhibitor huperzine A. The species is native to eastern Asia (China, Tibet, Japan, the Korean peninsula, the Russian Far East). (Source: Wiki)
Evidence Level
Level 4 (Individual reports repeated observed over 5 years among different countries)
Hepatotoxicity reports in literature
- Making a diagnosis of herbal-related toxic hepatitis : (Source)
- Case report: jin bu huan--not so benign herbal medicine : (Source)
- Acute hepatitis associated with the Chinese herbal product jin bu huan : (Source)
- Jin bu huan toxicity in adults--Los Angeles, 1993 : (Source)
- The clinical spectrum of Jin Bu Huan toxicity : (Source)
- Chronic hepatitis induced by Jin Bu Huan : (Source)
Hepatotoxicity Description
More than a dozen cases of hepatotoxicity attributable to products sold as Jin Bu Huan have been reported, with onset of liver test abnormalities or jaundice within 2 to 24 weeks of starting the herbal supplement. The enzyme pattern was typically hepatocellular, and the clinical syndrome resembled acute viral hepatitis with marked serum aminotransferase abnormalities and minimal increases in alkaline phosphatase levels. Fever, headache and dizziness were also common.
Eosinophilia
and rash have been reported but were not prominent, nor were autoantibodies frequent. In several instances, continuation of Jin Bu Huan led to chronic aminotransferase elevations and a syndrome that resembles chronic hepatitis. Recovery was usually within 1 to 2 months of stopping. Recurrence of hepatic injury with restarting Jin Bu Huan occurred and resulted in more severe injury. The reported cases were associated with a specific commercial preparation of Jin Bu Huan (Anodyne) and it is unclear whether the injury was due to the traditional herbal combination or to a contamination or mislabeling of the subsequently withdrawn commercial product. After withdrawal of the implicated product, there have been no further reports of liver injury related to Jin Bu Huan, which remains a popular and widely available Chinese herbal remedy. (Source: LiverTox)
Common name
N/A
ID
HD0039
Scientific name of the plant
Lypocodium serratum
Anatomical part for use
root
Human use
Pain and inflammation
Summary
Huperzia serrata, the toothed clubmoss, is a plant known as a firmoss which contains the acetylcholinesterase inhibitor huperzine A. The species is native to eastern Asia (China, Tibet, Japan, the Korean peninsula, the Russian Far East). (Source: Wiki)
Evidence Level
Level 4 (Individual reports repeated observed over 5 years among different countries)
Hepatotoxicity reports in literature
- Making a diagnosis of herbal-related toxic hepatitis : (Source)
- Case report: jin bu huan--not so benign herbal medicine : (Source)
- Acute hepatitis associated with the Chinese herbal product jin bu huan : (Source)
- Jin bu huan toxicity in adults--Los Angeles, 1993 : (Source)
- The clinical spectrum of Jin Bu Huan toxicity : (Source)
- Chronic hepatitis induced by Jin Bu Huan : (Source)
Hepatotoxicity Description
More than a dozen cases of hepatotoxicity attributable to products sold as Jin Bu Huan have been reported, with onset of liver test abnormalities or jaundice within 2 to 24 weeks of starting the herbal supplement. The enzyme pattern was typically hepatocellular, and the clinical syndrome resembled acute viral hepatitis with marked serum aminotransferase abnormalities and minimal increases in alkaline phosphatase levels. Fever, headache and dizziness were also common. Eosinophilia and rash have been reported but were not prominent, nor were autoantibodies frequent. In several instances, continuation of Jin Bu Huan led to chronic aminotransferase elevations and a syndrome that resembles chronic hepatitis. Recovery was usually within 1 to 2 months of stopping. Recurrence of hepatic injury with restarting Jin Bu Huan occurred and resulted in more severe injury. The reported cases were associated with a specific commercial preparation of Jin Bu Huan (Anodyne) and it is unclear whether the injury was due to the traditional herbal combination or to a contamination or mislabeling of the subsequently withdrawn commercial product. After withdrawal of the implicated product, there have been no further reports of liver injury related to Jin Bu Huan, which remains a popular and widely available Chinese herbal remedy. (Source: LiverTox)